[Dovecot] Real and Virtual Users + Domains

I have seen a few suggestions on how to address the issue of a system employing both real and virtual users and domains. Is there any definitive solution as to how this should be accomplished? The system I am construction will have several hundred users, both real and virtual, and probably seven domains. I plan on using MySQL to handle the user names and passwords.

-- Gerard

"Seen it all, done it all, can't remember most of it."

 Anonymous