Hi,
We're currently running a similar setup to what you 
describe:
-  
Dovecot-1.0.alpha4
-  
Maildir
-  Netapp/NFS 
exported mailstore (also home to the dovecot indices)
-  
mmap_disable=yes
-  
lock_method=fnctl
-  default 
actimeo (which correspond to the higher end of what 
you've observed)
Indices seem happy enough being served up from NFS.  That is, there's been no observable 
side-effects.
I would be very interested in hearing how you get on with 
multiple dovecot instances accessing the underlying mailstore/index files as 
this is a direction in which we're considering.
Regards,
John.